Health Desk-- Jun 15, 2017: Consuming extracts of broccoli may help people with Type 2 diabetes to manage their blood sugar, according to a recent study.
Type 2 diabetes affects around 450 million people worldwide and as many as 15 per cent of those patients cannot take the first-line therapy metformin because of kidney damage risks.
The findings showed that broccoli, which is also rich in sulforaphane, a naturally occurring compound found in cruciferous vegetables, may help reverse the disease signature.
In the study, conducted on rats, this compound reduced glucose production by liver cells that were growing in culture and shifted the liver gene expression away from a diseased state in the rats with diabetes.
For the study, appearing in the journal Science Translational Medicine, the team constructed a signature for Type 2 diabetes based on 50 genes, then used publically available expression datasets to screen 3,852 compounds for drugs that potentially reverse disease.
When the researchers gave concentrated broccoli sprout extracts to 97 human Type 2 diabetes patients in a 12-week randomised placebo-controlled trial, obese participants who had dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.