Tuesday, 13 Nov 2018

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New hope in curing Leukaemia

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Samia haque: 24 November, 2017: A group of US scientists have found a feasible way to cure the deadly disease lukaemia, that strikes patient as young as seven.

Leukemia is cancer of the blood or bone marrow (which produces blood cells). A person who has leukemia suffers from an abnormal production of blood cells, generally leukocytes (white blood cells).In 2015, leukemia was present in 2.3 million people and caused 353,500 deaths. It is the most common type of cancer in children, with three quarters of leukemia cases in children being the acute lymphoblastic type.

The study was published in the Journal Nature Medicine.The group from Stanford University and National Institute of Health (NIH) found that a molecule, called CD22, can serve as a potent target for the killer cells of acute lymphoblastic leukaemia, reports Xinhua news agency.

It works by genetically modifying a patient’s own immune cells to seek out and attack leukaemia cells that have a molecule called CD19 on their surface. This therapy relies on the patient’s own T cells — a type of immune cell that can become a powerful killing machine.

Stanford oncologist Crystal Mackall and NIH’s pediatric haematologist Terry Fry, discovered that a molecule called CD22 can be a similar target.

Scientists treated 21 patients with treatment-resistant B-cell leukaemia who are aged seven to 30 to test the new CD22-directed method.seventeen of them were previously treated with CD19-directed therapy and 15 of them had either relapsed or failed to respond.

They found that at the lowest dose level, one in six patients achieved complete remission after treatment, and with an escalated dose, 11 of 15 patients entered remission.