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Genetic cause of rare high blood pressure syndrome discovered

No icon Health Institute

Health Desk: 06 February 2018: A new study has discovered the genetic cause of a rare high blood pressure syndrome.

Professor Ute Scholl and a team of scientists from the United States and Australia have now identified a new hypertension disease gene. The study focused on a particular and very rare form of high blood pressure, known as familial hyper aldosteronism type II.

This inherited disease causes the adrenal gland to produce a high level of aldosterone - a hormone that regulates the water and salt conservation in the kidneys. Excess of this hormone in the body shoots up the blood pressure.

According to the research, more than a billion people worldwide suffer from hypertension or high blood pressure. Such a condition, if prolonged, damages blood vessels, which can result in damage to the heart, the kidneys, and the brain.

Possible consequences may include heart attack, kidney failure, and stroke. Besides obesity, salt consumption and alcohol intake, genetic factors play an important role in the development of hypertension.

In some rare cases, familial hypertension is caused by mutations in single genes. These genes play important roles in blood pressure determination. These mutations typically cause early-onset hypertension, even in young children and adolescents.

The findings from this study have been published in the scientific journal Nature Genetics.